Sun protection, vitamin D deficiency, and management of cutaneous oncology in organ transplant recipients (OTR).

نویسندگان

  • Jörg Reichrath
  • Kerstin Querings
چکیده

induces melanocytic hyperplasia in susceptible patients. J Am Acad Dermatol 33:577–583, 1995 Hachiya A, Kobayashi A, Ohuchi A, Takema Y, Imokawa G: The paracrine role of stem cell factor/c-kit signaling in the activation of human melanocytes in ultraviolet-B-induced pigmentation. J Invest Dermatol 116:578–586, 2001 Heissig B, Hattori K, Dias S, et al: Recruitment of stem and progenitor cells from the bone marrow niche requires MMP-9 mediated release of kit-ligand. Cell 109:625–637, 2002 Kanbe T, Soma Y, Kawa Y, Kashima M, Mizoguchi M: Serum levels of soluble stem cell factor and soluble KITare elevated in patients with atopic dermatitis and correlate with the disease severity. Br J Dermatol 144:1148–1153, 2001 Kligman LH, Murphy GF: Ultraviolet B radiation increases hairless mouse mast cells in a dose-dependent manner and alters distribution of UV-induced mast cell growth factor. Photochem Photobiol 63:123–127, 1996 Kunisada T, Lu SZ, Yoshida H, et al: Murine cutaneous mastocytosis and epidermal melanocytosis induced by keratinocyte expression of transgenic stem cell factor. J Exp Med 187:1565–1573, 1998 Longley BJ, Morganroth GS, Tyrrell L, Ding TG, Anderson DM, Williams DE, Halaban R: Altered metabolism of mast-cell growth factor (c-kit ligand) in cutaneous mastocytosis. New Engl J Med 328:1302–1307, 1993 Longley BJ, Tyrrell L, Ma Y, et al: Chymase cleavage of stem cell factor yields a bioactive, soluble product. Proc Natl Acad Sci USA 94:9017–9021, 1997 Pandiella A, Bosenberg MW, Huang EJ, Besmer P, Massague J: Cleavage of membrane-anchored growth factors involves distinct protease activities regulated through common mechanisms. J Biol Chem 267:24028–24033, 1992 Shimizu Y, Ashman LK, Du Z, Schwartz LB: Internalization of kit together with stem cell factor on human fetal liver-derived mast cells. J Immunol 156:3443–3449, 1996 Weiss RR, Whitaker-Menezes D, Longly J, Bender J, Murphy GF: Human dermal endothelial cells express membrane-associated mast cell growth factor. J Invest Dermatol 104:101–106, 1995 Yamamoto T, Sawada Y, Katayama I, Nishioka K: Local expression and systemic release of stem cell factor in systemic sclerosis with diffuse hyperpigmentation. Br J Dermatol 144:199–200, 2001

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Skin cancer in organ transplant recipients.

Organ transplant recipients (OTR) are at a significantly increased risk for developing a wide variety of skin cancers, particularly epithelial skin cancer, Merkel cell carcinoma and Kaposi's sarcoma. Melanoma, skin adnexal neoplasm and cutaneous lymphomas are also more common in OTR and may differ in their clinicopathologic presentation from tumors in immunocompetent patients. The accuracy of c...

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Prevention of non-melanoma skin cancer in organ transplant patients by regular use of a sunscreen: a 24 months, prospective, case-control study.

BACKGROUND Skin cancers represent a major challenge within the ever growing group of long time surviving organ transplant recipients (OTR) world wide. Especially UV-induced non-melanoma skin cancers (NMSC) like invasive squamous cell carcinomas (SCC) and actinic keratoses (AK), and basal cell carcinoma (BCC), outnumber every other form of cancer in organ transplant recipients. Despite encouragi...

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Calcidiol Deficiency in End-Stage Organ Failure and after Solid Organ Transplantation: Status quo

Among patients with organ failure, vitamin D deficiency is extremely common and frequently does not resolve after transplantation. This review crystallizes and summarizes existing data on the status quo of vitamin D deficiency in patients with organ failure and in solid organ transplant recipients. Interventional studies evaluating different treatment strategies, as well as current clinical pra...

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Treatment of Multiple Actinic Keratosis and Field of Cancerization with Topical Piroxicam 0.8% and Sunscreen 50+ in Organ Transplant Recipients: A Series of 10 Cases

Organ transplant recipient (OTR) subjects are at high risk of skin cancer such as squamous cell carcinoma and basal cell carcinoma. Actinic keratosis (AK) is considered the precursor of these non-melanoma skin cancers. Sun protection is mandatory in subjects with AK and this preventive strategy is very important in OTR. Treatment of the field of cancerization is also crucial to reduce the risk ...

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Serum vitamin D levels in kidney transplant recipients: the importance of an immunosuppression regimen and sun exposure.

BACKGROUND Vitamin D deficiency was shown to be prevalent among renal transplant recipients in northern countries, but little is known regarding risk factors. OBJECTIVES To test vitamin D levels in kidney transplant recipients residing closer to the equator, compare them to levels in liver transplant recipients and hemodialysis patients, and identify possible risk factors. METHODS In a cros...

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عنوان ژورنال:
  • The Journal of investigative dermatology

دوره 124 5  شماره 

صفحات  -

تاریخ انتشار 2005